AAbstract | 2-aminothiazoles are very important heterocyclic compounds in medicinal chemistry and
applied as a ligand in estrogen receptor [1]. In the recent years, application of modified
magnetic nanoparticle (Fe3O4) as a reusable and highly stable magnetic nanoparticle has
attracted much attention in 2-aminothiazole synthesis [2]. Among many materials, graphene
and its derivatives are considered potential materials for the immobilization of nanoparticles.
In the present study, Fe3O4/GO/TiO2 nanocomposite was prepared by a sol-gel method for
titania coating on Fe3O4/GO. The Fe3O4/GO/TiO2 composite particles were characterized by
FT-IR and T -bromo Acetophenones in
the presence of (Fe3O4/GO/TiO2) catalyst affording the desired 2-aminothiazoles in high yields.
In conclusion, we have successfully demonstrate for the first time that Fe3O4/GO/TiO2
composite could be used as an efficient solid recyclable magnetic nanocatalyst for convenient
synthesis of 2-aminothiazole derivatives under mild conditions. The novelty and synthetic
volubility of this method developed the mild reaction conditions, easy experimental procedure,
avoiding the use of organic solvents and recovery of the magnetic nanocatalyst |